후성유전학 연구를 통한 질병의 발병기전 및 치료 타겟 규명
신호전달물질과 후성유전의 네트워크 연구
학력
(Ph.D.) 독일, Ruhr University Bochum, 이학박사
약력/경력
1992 - 1995 스위스, Friedrich Miescher Institute, Post-doc
1996 - 2006 성균관대학교 약학대학, 부교수
2002 - 2003 미국, National Institute of Health, 방문교수
2006 - 현재 성균관대학교 약학대학 교수
2010 - 현재 미래부?한국연구재단 선도연구센터 (MRC, 에피지놈 제어 연구센터) 센터장
학술지 논문
(2022)
Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain.
GeroScience.
44,
4
(2022)
Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera).
JOURNAL OF GINSENG RESEARCH.
46,
3
(2022)
Nuclear S6K1 regulates cAMP-responsive element-dependent gene transcription through activation of mTOR signal pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
594,
(2022)
Rg3 and Rh2 ginsenosides suppress embryoid body formation by inhibiting the epithelial-mesenchymal transition.
ARCHIVES OF PHARMACAL RESEARCH.
45,
7
(2022)
S6K1 controls adiponectin expression by inducing a transcriptional switch: BMAL1-to-EZH2.
EXPERIMENTAL AND MOLECULAR MEDICINE.
54,
3
(2022)
The EEF1AKMT3/MAP2K7/TP53 axis suppresses tumor invasiveness and metastasis in gastric cancer.
CANCER LETTERS.
544,
(2021)
Phytochemical constituents identified from the aerial parts of lespedeza cuneata and their effects on lipid metabolism during adipocyte maturation.
SEPARATIONS.
8,
11
(2021)
Nucleoporin 210 Serves a Key Scaffold for SMARCB1 in Liver Cancer.
CANCER RESEARCH.
81,
2
(2020)
Rosmarinic Acid Methyl Ester Regulates Ovarian Cancer Cell Migration and Reverses Cisplatin Resistance by Inhibiting the Expression of Forkhead Box M1.
PHARMACEUTICALS.
13,
10
(2020)
Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 Pseudovirus.
VIRUSES-BASEL.
12,
9
(2020)
HP1 gamma Sensitizes Cervical Cancer Cells to Cisplatin through the Suppression of UBE2L3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
21,
17
(2020)
In vitro modeling for inherited neurological diseases using induced pluripotent stem cells: from 2D to organoid.
ARCHIVES OF PHARMACAL RESEARCH.
43,
9
(2020)
Fermented Ginseng Extract, BST204, Suppresses Tumorigenesis and Migration of Embryonic Carcinoma through Inhibition of Cancer Stem Cell Properties.
MOLECULES.
25,
14
(2020)
Isoprenylcysteine Carboxyl Methyltransferase and Its Substrate Ras Are Critical Players Regulating TLR-Mediated Inflammatory Responses.
CELLS.
9,
5
(2020)
HPV-mediated nuclear export of HP1 gamma drives cervical tumorigenesis by downregulation of p53.
CELL DEATH AND DIFFERENTIATION.
27,
9
(2020)
Ginsenoside Rg3 Induces Browning of 3T3-L1 Adipocytes by Activating AMPK Signaling.
NUTRIENTS.
12,
2
(2020)
Fermented ginseng extract, BST204, disturbs adipogenesis of mesenchymal stem cells through inhibition of S6 kinase 1 signaling.
JOURNAL OF GINSENG RESEARCH.
44,
1
(2019)
Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer.
BMC CANCER.
19,
1
단행본
(2010)
약품생화학총정리.
동명사.
공동
(2005)
리핀코트의 그림으로 보는 생화학.
신일상사.
공동
(2003)
분자약품 생화학.
동명사.
공동
(2001)
약품생화학실험.
동명사.
공동
(2000)
영양과 건강.
성균관대학교 출판부.
공동
수상/공훈
대한약학회 국제 협력위원장
응용약물학회 편집위원
Archives of Pharmacal Research 편집위원
한국연구재단 의약학단 전문위원
수상경력 : 성균관대학교 우수연구자상 (Premier Researcher) (2008)
학술회의논문
(2019)
Epigenetic role of S6K1 in adipogenic gene regulation.
제 71차 대한약리학회 추계학술대회.
대한민국
(2018)
BST204, fermented ginseng extract, inhibits S6K1 signaling to disturb adipogenesis.
2018 Fall International Convention of
The Pharmaceutical Society of Korea.
대한민국
(2018)
HPV E6-mediated nuclear export of HP1drives p53 degradation in cervical cancer.
2018 Fall International Convention of The Pharmaceutical Society of Korea.
대한민국
(2018)
Rosmarinic acid methyl ester suppressed cisplatin resistance in cervical cancer cell by
mediating autophagy and apoptosis through S6K1 inhibition.
2018 Fall International Convention of The Pharmaceutical Society of Korea.
대한민국
(2018)
Generation and characterization of cisplatin resistant cancer cell-lines.
2018 Spring International Convention of
The Pharmaceutical Society of Korea.
대한민국
(2017)
Overcoming HPV-mediated p53 degradation system with epigenetic reader HP1.
World Congress on Virology & Infectious Disease.
미국
(2017)
S6K1-mediated epigenetic plasticity for α to β cell transition.
2017 Fall International Convention of The Pharmaceutical Society of Korea.
대한민국
(2017)
Silencing of microRNA-133 by the small molecule reversine promotes white adipose tissue browning.
2017 Fall International Convention of The Pharmaceutical Society of Korea.
대한민국
(2017)
HDAC Inhibitor Suppresses Tumorigenicity and Metastasis via Down-regulating Cancer Stem Cell Marker CD133.
2017 Spring International Convention of The Pharmaceutical Society of Korea.
대한민국
(2017)
Nuclear export of HP1γ is responsible for HPV-mediated p53 degradation in cervical cancer.
2017 Spring International Convention of The Pharmaceutical Society of Korea.
대한민국
(2017)
Tumour Suppressor p53 is Regulated by the Lysine Demethylase KDM2B.
2017 Spring International Convention of The Pharmaceutical Society of Korea.
대한민국
(2017)
S6K1-Mediated Histone Crosstalk: A Determinant of Early Adipogenesis.
Chromatin and epigenetics: from mechanism to function.
독일
(2016)
Metabolism and Histone modification.
기초의과학연구센터 2016 연합성과발표회.
대한민국
(2016)
Overcoming cervical cancer-specific p53 degradation system with an epigenetic reader HP1γ.
기초의과학연구센터 2016 연합성과발표회.
대한민국
(2016)
Basic concept and clinical application of epigenetic
modulation.
2016년 제22차 추계학술대회 및 정기총회.
대한민국
(2016)
Overcoming cervical cancer-specific p53 degradation system with epigenetic reader HP1.
International Conference on 70th Anniversary of The Pharmaceutical Society of Korea.
대한민국
(2016)
Control of adipogenesis by S6K1-mediated epigenetic modifications.
Internaional Conference on Diabetes and Metabolism.
대한민국
(2016)
S6K1-Mediated Epigenetic Modifications: A Determinant of Early Adipogenesis.
ZING CONFERENCES.
크로아티아
(2016)
Identification of S6k1 inhibitors for prevention of obesity.
2016 International Convention of The Pharmaceutical Society of Korea.
대한민국
(2016)
S6K1 regulates the plasticity of α cell/β cell through epigenetic modifications.
2016 Spring
International Convention of
한국과학기술단체총연합회, 식품의약품안전처, 한국제약협회, (사)대한약사회, 광주광역시청
광주관2016 International Convention of The Pharmaceutical Society of Korea.
대한민국
